Pillgwenlly (Welsh: Pillgwen-lli) is an electoral district (ward) and coterminous community (parish) of the city of Newport. Its name comes from 'Pill' the Welsh language word for a water inlet or harbour and 'Gwenlly' a corruption of the name of Saint Gwynllyw, the name meaning Gwynllyw's harbour. Supposedly it derives from the period when Gwynllyw was a pirate and he based his ships in this area.

The ward is bounded by the River Usk to the east and southeast, the Ebbw River to the southwest, the Great Western Main Line to the west and Cardiff Road to the north. It is an inner-city district to the south of the city centre and the built-up area is commonly shortened to "Pill". It contains the Newport Docks and the western ends of the Newport Transporter Bridge, City Bridge and George Street Bridge.

The ward is currently one of the most economically deprived in Wales with a very high rate of unemployment and has been in the press for the wrong reasons in recent years; hence it suffers from a bad reputation. However, Pill is also known for its close-knit community spirit and ethnic diversity. The streets of Pill play host to the Pill Carnival on the last weekend of every August. The Old Town Dock area is currently undergoing a huge mixed-use regeneration to bring the derelict dock lands back into use.

Pill Harriers RFC is a successful rugby union team playing in the Welsh Division 2.