Cross Keys will host Moseley at Pandy Park when they make their British & Irish Cup debut on November 12.
The following week Cross Keys will travel to Scotland to tackle Ayr on November 19.
Cross Keys, Neath, Aberavon, Llanelli, Pontypridd and Swansea will fly the flag for Wales in a tournament which will kick off with a clash of previous winners when Bristol Rugby travel to Cornish Pirates.
“We have always aspired to play in the British & Irish Cup and kicking-off up in Scotland is fantastic,” said Keys head coach Greg Woods.
“There has been a real buzz around the village and club about playing in the tournament and we are treating the matches as our marquee fixtures – we want to make a real impact in the competition.”
The third British & Irish Cup will see a change in format, with a cross-Pool fixture list which guarantees two home fixtures for each side and with all English ties played in midweek to ease potential weekend fixture congestion.
Pool 1: Ayr, Cornish Pirates, Moseley, Neath,
Pool 2: Bristol Rugby, Cross Keys, Plymouth Albion, Munster
Pool 3: Aberavon, Bedford Blues, Leinster, London Scottish
Pool 4: Esher Rugby, Llanelli, London Welsh, Melrose
Pool 5: Currie, Doncaster Knights, Rotherham Titans, Pontypridd
Pool 6: Leeds Carnegie, Nottingham Rugby, Swansea, Ulster,
Round 1 (September 21): Cornish Pirates v Bristol Rugby, Moseley v Plymouth, London Scottish v London Welsh, Bedford Blues v Esher, Nottingham Rugby v Doncaster Knights, Leeds Carnegie v Rotherham Titans. (November 19): Neath v Munster, Ayr v Cross Keys, Aberavon v Llanelli, Leinster v Melrose, Currie v Ulster, Pontypridd v Swansea
Round 2 (October 12): Plymouth v Cornish Pirates, Bristol Rugby v Mosley, Esher v London Scottish, London Welsh v Bedford Blues, Doncaster Knights v Leeds Carnegie, Rotherham Titans v Nottingham Rugby. (December 10): Munster vs. Ayr, Llanelli v Leinster, Ulster v Pontypridd, Cross Keys v Neath, Melrose v Aberavon, Swansea v Currie
Round 3 (November 12): Cross Keys v Moseley, Munster v Cornish Pirates, Bristol Rugby v Neath, Plymouth v Ayr, Melrose v Bedford Blues, Llanelli v London Scottish, London Welsh v Aberavon, Esher v Leinster, Swansea v Rotherham Titans, Ulster v Doncaster Knights, Leeds Carnegie v Currie, Nottingham Rugby v Pontypridd
Round 4 (December 17): Mosley v Munster, Cornish Pirates v Cross Keys, Neath v Plymouth, Ayr v Bristol Rugby, Bedford Blues v Llanelli, London Scottish v Melrose, Aberavon v Esher, Leinster v London Welsh, Rotherham Titans v Ulster, Doncaster Knights v Swansea, Currie v Nottingham Rugby, Pontypridd v Leeds Carnegie
Quarter finals: January 21, 2012
Semi finals: April 7
Final: April 28
